As a critical evaluation tool for future drug development, organoids hold significant potential to replace animal testing and even partially substitute for human clinical trials. This has attracted considerable attention from basic research to applied sciences and the capital markets worldwide.

Seizing the technological opportunity, Exclcirc (Suzhou) Biomedical Co., Ltd. has actively introduced an organoid technology platform. We have successfully completed several self-developed circRNA technology evaluations and assessments of other types of drug molecules, accumulating extensive hands-on experience with organoids during this process.

The liver, a vital metabolic organ in the human body, participates in numerous physiological processes, such as nutrient metabolism, lipid and cholesterol balance, and degradation of foreign compounds. However, due to the lack of effective in vitro models, research on liver diseases and drug development has long faced significant challenges.

Exclcirc BioMed has developed liver organoids based on human liver tissue, which can stably expand over the long term in vitro. These organoids can be used for expression detection of gene therapies and are expected to simulate various metabolic functions of the liver, providing an ideal in vitro model for related research.

The organoid models we provide exhibit gene expression patterns highly similar to those of primary human hepatocytes across multiple categories related to liver cell metabolic functions, including fatty acid metabolism and drug metabolism. Based on transcriptomic profiling, we can predict potential pathways of action in drug metabolism or target prediction.

In addition, we offer customized organoid services for the liver, kidney, lung, and other organs according to client needs. Similarly, we provide end-to-end CRO services,  from cell source selection and culture optimization to organoid characterization, tailored to the specific requirements of different lients.

Figure 1: Results of Liver Organoid Induction and Differentiation

Figure 2 ^{[1, 2]}: Structure of Liver Organoids

References

[1] Igarashi R, Oda M, Okada R, et al. Generation of human adult hepatocyte organoids with metabolic functions. Nature. 2025;641(8065):1248-1257. doi:10.1038/s41586-025-08861-y
[2] Dowbaj AM, Sljukic A, Niksic A, et al. Mouse liver assembloids model periportal architecture and biliary fibrosis. Nature. 2025;644(8076):473-482. doi:10.1038/s41586-025-09183-9